Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26580968 | 0.79 | HRH4 (0.55) | HRH4TP53HSD17B10KMT2ANPSR1 | |
| SCHEMBL27082996 | 0.76 | HRH4 (0.59) | HRH4KMT2AHTR6 | |
| SCHEMBL20604725 | 0.76 | KMT2A (0.56) | HRH4TP53HSD17B10KMT2ANPSR1 | |
| SCHEMBL26037956 | 0.76 | HRH4 (0.61) | HRH4KMT2A | |
| SCHEMBL23808976 | 0.73 | ALDH1A1 (0.41) | — | |
| SCHEMBL12257800 | 0.73 | HRH4 (0.74) | HRH4TP53HSD17B10KMT2ANPSR1 | |
| SCHEMBL22924654 | 0.73 | HRH4 (0.74) | HRH4TP53HSD17B10KMT2ANPSR1 | |
| SCHEMBL20604872 | 0.72 | HRH4 (0.47) | HRH4TP53HSD17B10KMT2ANPSR1 | |
| SCHEMBL8171578 | 0.69 | HRH4 (0.65) | HRH4HSD17B10KMT2ANPSR1 | |
| SCHEMBL11988216 | 0.68 | ADRB1 (0.49) | HRH4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | HRH4 4602/4885TP53 30/4885HSD17B10 3627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.