Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | KRAS | P01116 | 3/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30872206 | 0.82 | ALDH1A1 (0.40) | ALDH1A1GAATSHRKDM4EHPGD | |
| SCHEMBL9924223 | 0.82 | ALDH1A1 (0.40) | ALDH1A1GAATSHRKDM4EHPGD | |
| SCHEMBL27531475 | 0.79 | ALDH1A1 (0.38) | ALDH1A1GAAKDM4EHPGDS1PR1 | |
| SCHEMBL8104228 | 0.76 | ALDH1A1 (0.55) | ALDH1A1GAATSHRKDM4EHPGD | |
| SCHEMBL25628271 | 0.75 | KRAS (0.43) | ALDH1A1GAATSHRKDM4EHPGD | |
| SCHEMBL287031 | 0.75 | ALDH1A1 (0.42) | ALDH1A1GAAKDM4EHPGDKRAS | |
| SCHEMBL8200797 | 0.75 | DPP4 (0.40) | ALDH1A1GAATSHRKDM4EHPGD | |
| SCHEMBL1151568 | 0.73 | ALDH1A1 (0.59) | ALDH1A1GAAKDM4EHPGDS1PR1 | |
| SCHEMBL10216198 | 0.72 | CYP2A6 (0.44) | TSHRKDM4EHPGDKMT2ATYMS | |
| SCHEMBL27506477 | 0.72 | ALDH1A1 (0.42) | ALDH1A1GAATSHRKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | ALDH1A1 2556/4885GAA 3420/4885TSHR 4309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.