Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23809239 | 0.88 | MEN1 (0.36) | MCL1RIPK1 | |
| SCHEMBL26581706 | 0.87 | MCL1 (0.33) | IRAK4MCL1 | |
| SCHEMBL20605065 | 0.85 | HASPIN (0.37) | IRAK4MCL1 | |
| SCHEMBL23809465 | 0.79 | MTNR1A (0.37) | MCL1RIPK1 | |
| SCHEMBL23809296 | 0.79 | GRM5 (0.47) | IRAK4MCL1RIPK1 | |
| SCHEMBL23809218 | 0.78 | DRD2 (0.42) | MCL1 | |
| SCHEMBL23799645 | 0.78 | HSD11B1 (0.41) | — | |
| SCHEMBL26581668 | 0.75 | MCL1 (0.39) | MCL1RIPK1 | |
| SCHEMBL23809246 | 0.74 | MEN1 (0.43) | RIPK1 | |
| SCHEMBL23809238 | 0.73 | HSD17B2 (0.34) | MCL1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | IRAK4 1956/4885MCL1 1/4885RIPK1 560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.