Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CCR9 | P51686 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6839017 | 0.72 | ALDH1A1 (0.62) | ALDH1A1POLBCYP1A2TSHRHTT | |
| SCHEMBL6838172 | 0.72 | ALDH1A1 (0.62) | ALDH1A1POLBCYP1A2TSHRHTT | |
| SCHEMBL6750523 | 0.70 | ALDH1A1 (0.97) | ALDH1A1POLBCYP1A2TSHRHTT | |
| SCHEMBL23809172 | 0.70 | ALDH1A1 (0.60) | ALDH1A1POLBCYP1A2TSHRHTT | |
| SCHEMBL26036899 | 0.68 | KDM4E (0.39) | ALDH1A1POLBCYP1A2GPR35KDM4E | |
| SCHEMBL6753579 | 0.68 | ALDH1A1 (0.67) | ALDH1A1POLBCYP1A2TSHRHTT | |
| SCHEMBL6838506 | 0.68 | ALDH1A1 (0.67) | ALDH1A1POLBCYP1A2TSHRHTT | |
| SCHEMBL26581456 | 0.67 | ALDH1A1 (0.40) | ALDH1A1GPR35KDM4EHPGDHSD17B10 | |
| SCHEMBL23809370 | 0.66 | DHODH (0.39) | ALDH1A1POLBCYP1A2GPR35KDM4E | |
| SCHEMBL26590807 | 0.65 | ALDH1A1 (0.38) | ALDH1A1GPR35KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | ALDH1A1 2556/4885POLB 2458/4885CYP1A2 4125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.