Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | RARA | P10276 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.39 |
| ▸ | SELPLG | Q14242 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177930 | 0.88 | ALOX15 (0.45) | ALOX15GPR35ALDH1A1LMNAKCNK3 | |
| SCHEMBL30541959 | 0.84 | ALOX15 (0.68) | ALOX15GPR35ALDH1A1PDE10AKDM4E | |
| SCHEMBL30541958 | 0.84 | ALOX15 (0.68) | ALOX15GPR35ALDH1A1PDE10AKDM4E | |
| SCHEMBL551212 | 0.84 | ALOX15 (0.68) | ALOX15GPR35ALDH1A1PDE10AKDM4E | |
| SCHEMBL1811064 | 0.83 | ALOX15 (0.66) | ALOX15GPR35ALDH1A1PDE10AKDM4E | |
| Potassium SCHEMBL1811070 | 0.83 | ALOX15 (0.66) | ALOX15GPR35ALDH1A1PDE10AKDM4E | |
| SCHEMBL1815345 | 0.82 | ALOX15 (0.64) | ALOX15GPR35ALDH1A1PDE10AKDM4E | |
| SCHEMBL29531273 | 0.82 | ALOX15 (0.64) | ALOX15GPR35ALDH1A1PDE10AKDM4E | |
| SCHEMBL30421043 | 0.81 | ALOX15 (0.62) | ALOX15GPR35ALDH1A1LMNAPDE10A | |
| SCHEMBL7697377 | 0.79 | LMNA (0.48) | ALDH1A1LMNAKCNK3KCNK9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | ALOX15 3067/4885GPR35 3148/4885ALDH1A1 2556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.