Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26581238 | 0.85 | NPC1 (0.47) | SLC22A12NPC1KDM4EHCAR3MCL1 | |
| SCHEMBL23809482 | 0.78 | SLC22A12 (0.49) | SLC22A12ACE2KDM4EHCAR3HPGD | |
| SCHEMBL30166598 | 0.77 | NPC1 (0.41) | SLC22A12NPC1MCL1PLA2G4APTPN1 | |
| SCHEMBL23809463 | 0.76 | SLC22A12 (0.52) | SLC22A12ACE2KDM4EHCAR3PLA2G4A | |
| SCHEMBL23855061 | 0.76 | NPC1 (0.40) | SLC22A12NPC1MCL1PLA2G4AEGFR | |
| SCHEMBL23809523 | 0.75 | SLC22A12 (0.51) | SLC22A12ACE2KDM4EHCAR3PLA2G4A | |
| SCHEMBL28878014 | 0.75 | DGAT1 (0.41) | SLC22A12NPC1MCL1PTPN1EGFR | |
| SCHEMBL23809221 | 0.74 | HCAR3 (0.40) | SLC22A12ACE2KDM4EHCAR3PLA2G4A | |
| SCHEMBL28090346 | 0.74 | HSP90AA1 (0.40) | NPC1HPGD | |
| SCHEMBL23809481 | 0.74 | SLC22A12 (0.53) | SLC22A12ACE2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210283138-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | SLC22A12 3136/4885NPC1 2467/4885ACE2 4387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.