Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 17/20 | 0.49 |
| ▸ | CCR2 | P41597 | 16/20 | 0.49 |
| ▸ | QPCT | Q16769 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2383017 | 0.86 | QPCT (0.52) | QPCT | |
| SCHEMBL2382908 | 0.86 | QPCT (0.50) | QPCT | |
| SCHEMBL2380742 | 0.85 | QPCT (0.46) | QPCT | |
| SCHEMBL2383102 | 0.85 | QPCT (0.44) | QPCT | |
| SCHEMBL2383103 | 0.82 | QPCT (0.48) | QPCT | |
| SCHEMBL2381493 | 0.80 | QPCT (0.50) | QPCT | |
| SCHEMBL2383772 | 0.79 | QPCT (0.49) | QPCT | |
| SCHEMBL2380955 | 0.78 | QPCT (0.61) | QPCT | |
| SCHEMBL2382973 | 0.74 | QPCT (0.52) | QPCT | |
| SCHEMBL2379722 | 0.73 | QPCT (0.66) | QPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545047-B9 | HETEROCYCLIC INHIBITORS OF GLUTAMINYL CYCLASE (QC, EC 2.3.2.5) | PROBIODRUG AG (DE) | 2015-06-10 | — | — | EP | disclosed |
| EP-2545047-B1 | HETEROCYCLIC INHIBITORS OF GLUTAMINYL CYCLASE (QC, EC 2.3.2.5) | PROBIODRUG AG (DE) | 2014-04-23 | — | — | EP | disclosed |
| US-8420828-B2 | Inhibitors | PROBIODRUG AG (DE) | 2013-04-16 | — | — | US | disclosed |
| EP-2545047-A1 | HETEROCYCLIC INHIBITORS OF GLUTAMINYL CYCLASE (QC, EC 2.3.2.5) | Probiodrug AG (DE) | 2013-01-16 | — | — | EP | disclosed |
| US-20120283259-A1 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2012-11-08 | — | — | US | disclosed |
| US-8269019-B2 | Inhibitors | PROBIODRUG AG (DE) | 2012-09-18 | — | — | US | disclosed |
| WO-2011110613-A1 | HETEROCYCLIC INHIBITORS OF GLUTAMINYL CYCLASE (QC, EC 2.3.2.5) | PROBIODRUG AG (DE) | 2011-09-15 | — | — | WO | disclosed |
| US-20110224254-A1 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224254-A1 | NOVEL INHIBITORS | GLUL, QPCT, GLS | CCR1 4840/4885CCR2 4629/4885QPCT 2/4885 |
| US-20120283259-A1 | NOVEL INHIBITORS | GLUL, QPCT, GLS | CCR1 4840/4885CCR2 4629/4885QPCT 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.