Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 15/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2383187 | 0.88 | QPCT (0.52) | QPCTDRD2IP6K1KDM4EALDH1A1 | |
| SCHEMBL2382908 | 0.87 | QPCT (0.50) | QPCTIP6K1 | |
| SCHEMBL2381865 | 0.86 | CCR1 (0.49) | QPCT | |
| SCHEMBL2383102 | 0.85 | QPCT (0.44) | QPCT | |
| SCHEMBL1443991 | 0.77 | QPCT (0.58) | QPCTIP6K1 | |
| SCHEMBL2379722 | 0.77 | QPCT (0.66) | QPCT | |
| SCHEMBL2380955 | 0.77 | QPCT (0.61) | QPCTIP6K1 | |
| SCHEMBL2381493 | 0.75 | QPCT (0.50) | QPCT | |
| SCHEMBL2381376 | 0.75 | QPCT (0.49) | QPCTIP6K1 | |
| SCHEMBL2380742 | 0.75 | QPCT (0.46) | QPCTIP6K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545047-B9 | HETEROCYCLIC INHIBITORS OF GLUTAMINYL CYCLASE (QC, EC 2.3.2.5) | PROBIODRUG AG (DE) | 2015-06-10 | — | — | EP | disclosed |
| EP-2545047-B1 | HETEROCYCLIC INHIBITORS OF GLUTAMINYL CYCLASE (QC, EC 2.3.2.5) | PROBIODRUG AG (DE) | 2014-04-23 | — | — | EP | disclosed |
| US-8420828-B2 | Inhibitors | PROBIODRUG AG (DE) | 2013-04-16 | — | — | US | disclosed |
| EP-2545047-A1 | HETEROCYCLIC INHIBITORS OF GLUTAMINYL CYCLASE (QC, EC 2.3.2.5) | Probiodrug AG (DE) | 2013-01-16 | — | — | EP | disclosed |
| US-20120283259-A1 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2012-11-08 | — | — | US | disclosed |
| US-8269019-B2 | Inhibitors | PROBIODRUG AG (DE) | 2012-09-18 | — | — | US | disclosed |
| WO-2011110613-A1 | HETEROCYCLIC INHIBITORS OF GLUTAMINYL CYCLASE (QC, EC 2.3.2.5) | PROBIODRUG AG (DE) | 2011-09-15 | — | — | WO | disclosed |
| US-20110224254-A1 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224254-A1 | NOVEL INHIBITORS | GLUL, QPCT, GLS | QPCT 2/4885DRD2 4529/4885IP6K1 2750/4885 |
| US-20120283259-A1 | NOVEL INHIBITORS | GLUL, QPCT, GLS | QPCT 2/4885DRD2 4529/4885IP6K1 2750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.