Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.66 |
| ▸ | SENP8 | Q96LD8 | 4/20 | 0.66 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.66 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.66 |
| ▸ | NPC1 | O15118 | 10/20 | 0.65 |
| ▸ | RAB9A | P51151 | 10/20 | 0.65 |
| ▸ | MEN1 | O00255 | 7/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | LMNA | P02545 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | HSPA5 | P11021 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.52 |
| ▸ | RELA | Q04206 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23818455 | 0.89 | HSPA5 (0.70) | CASP3SENP8SENP7SENP6NPC1 | |
| SCHEMBL23818758 | 0.88 | CASP3 (0.66) | CASP3SENP8SENP7SENP6NPC1 | |
| SCHEMBL23804599 | 0.81 | CASP3 (0.69) | CASP3SENP8SENP7SENP6NPC1 | |
| SCHEMBL4918421 | 0.81 | CASP3 (1.00) | CASP3SENP8SENP7SENP6NPC1 | |
| SCHEMBL23818760 | 0.72 | HSPA5 (1.00) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL3038955 | 0.70 | HSPA5 (0.60) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL13222393 | 0.70 | HSPA5 (0.60) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL161765 | 0.69 | NPC1 (0.66) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL9036463 | 0.69 | NPC1 (0.74) | CASP3SENP8SENP7SENP6NPC1 | |
| SCHEMBL30553310 | 0.69 | NPC1 (0.74) | CASP3SENP8SENP7SENP6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021183942-A1 | INHIBITORS OF HSP70 PROTEINS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2021-09-16 | — | — | WO | disclosed |