Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CAD | P27708 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10381604 | 0.78 | KDM4E (0.41) | SLC1A3SLC1A2SLC1A1TGFBR1ALDH1A1 | |
| SCHEMBL363847 | 0.73 | TSHR (0.52) | SLC1A3SLC1A2SLC1A1TGFBR1LMNA | |
| SCHEMBL2485440 | 0.72 | — | — | |
| SCHEMBL36898 | 0.72 | — | — | |
| SCHEMBL1120209 | 0.72 | — | — | |
| SCHEMBL8760692 | 0.71 | ALDH1A1 (0.38) | SLC1A3SLC1A2SLC1A1ALDH1A1 | |
| SCHEMBL867266 | 0.70 | — | — | |
| SCHEMBL10899226 | 0.70 | — | — | |
| SCHEMBL21676665 | 0.68 | TP53 (0.35) | SLC1A3SLC1A2SLC1A1ALDH1A1 | |
| SCHEMBL8849737 | 0.68 | SLC1A3 (0.35) | SLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492344-B2 | PDK inhibitor compounds and methods of use thereof | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2013-07-23 | — | — | US | claimed |
| US-8492344-B2 | PDK inhibitor compounds and methods of use thereof | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2013-07-23 | — | — | US | disclosed |
| US-20120004284-A1 | PDK INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2012-01-05 | — | — | US | disclosed |
| WO-2010027458-A2 | PDK INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-03-11 | — | — | WO | disclosed |
| US-4672101-A | Polyepoxy aromatic hydantoins | THE DOW CHEMICAL COMPANY (US) | 1987-06-09 | — | — | US | disclosed |