SCHEMBL23819693

SCHEMBL23819693

O=C(Cl)Oc1ccc(Cl)c(F)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA3 P32297 1/20 0.50
PPARG P37231 1/20 0.48
PPARA Q07869 1/20 0.48
HRH3 Q9Y5N1 1/20 0.44
ATF4 P18848 10/20 0.41
ICAM1 P05362 1/20 0.39
SELE P16581 1/20 0.39
SLC6A4 P31645 3/20 0.38
KCNQ3 O43525 1/20 0.38
KCNQ2 O43526 1/20 0.38
KCNE1 P15382 1/20 0.38
KCNQ1 P51787 1/20 0.38
ALDH1A1 P00352 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
MAPT P10636 1/20 0.37
CYP2C9 P11712 1/20 0.37
HPGD P15428 1/20 0.37
CYP2C19 P33261 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31126239 0.84 CES2 (0.43) CHRNA3MAPTKMT2A
SCHEMBL4805336 0.84 CES2 (0.43) CHRNA3MAPTKMT2A
SCHEMBL5260935 0.83 MEN1 (0.52) CHRNA3PPARGPPARAHRH3ATF4
SCHEMBL3331532 0.83 CHRNA3 (0.49) CHRNA3PPARGPPARASLC6A4CYP3A4
SCHEMBL1587868 0.82 KDM4E (0.47) CHRNA3PPARGPPARAHRH3SLC6A4
SCHEMBL3879835 0.79 MRGPRX4 (0.44) KCNQ3KCNQ2KCNE1KCNQ1ALDH1A1
SCHEMBL31506663 0.78 PPARG (0.46) CHRNA3PPARGPPARAHRH3ATF4
SCHEMBL21436881 0.77 ATF4 (0.53) PPARGPPARAHRH3ATF4MAPT
SCHEMBL4780465 0.76 HTR2A (0.39) SLC6A4ALDH1A1MAPTKMT2ATDP1
SCHEMBL6564497 0.74 KMT2A (0.48) ALDH1A1MAPTKMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021180774-A1 MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY EVOTEC INTERNATIONAL GMBH (DE) 2021-09-16 WO disclosed