Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15495181 | 0.83 | WDR5 (0.41) | DHODHWDR5SMN1; SMN2HSP90AA1AKR1C2 | |
| SCHEMBL23823369 | 0.79 | AKR1C2 (0.53) | SMN1; SMN2AKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL18394239 | 0.78 | GAA (0.47) | DHODHSMN1; SMN2HPGDGAAPOLB | |
| SCHEMBL29608104 | 0.78 | GAA (0.47) | DHODHSMN1; SMN2HPGDGAAPOLB | |
| SCHEMBL23604718 | 0.78 | WDR5 (0.46) | DHODHWDR5SMN1; SMN2AKR1C2AKR1C1 | |
| SCHEMBL19321444 | 0.76 | AKR1C4 (0.60) | WDR5AKR1C2AKR1C1AKR1C4AKR1C3 | |
| SCHEMBL14401952 | 0.75 | GPR27 (0.44) | DHODHSMN1; SMN2HSP90AA1ALDH1A1HPGD | |
| SCHEMBL30474394 | 0.73 | HSP90AA1 (0.57) | SMN1; SMN2HSP90AA1HPGD | |
| SCHEMBL12658712 | 0.73 | HSP90AA1 (0.57) | SMN1; SMN2HSP90AA1HPGD | |
| SCHEMBL21416021 | 0.73 | WDR5 (0.58) | WDR5SMN1; SMN2AKR1C2AKR1C1AKR1C4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021180235-A1 | INHIBITOR OF ENHANCER OF ZESTE HOMOLOGUE 2, AND USE THEREOF | 四川海思科制药有限公司 | 2021-09-16 | — | — | WO | disclosed |