Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.66 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 13/20 | 0.46 |
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23828290 | 0.79 | CFTR (1.00) | CFTRBAZ2BKDRKDM4EMAPT | |
| SCHEMBL30570539 | 0.79 | CFTR (1.00) | CFTRBAZ2BKDRKDM4EMAPT | |
| SCHEMBL11736040 | 0.69 | SIRT1 (1.00) | SIRT1MAPKAPK2MAPKAPK5MAPT | |
| SCHEMBL23828230 | 0.66 | CFTR (0.77) | CFTRBAZ2BMAPTHDAC1HDAC6 | |
| SCHEMBL30570546 | 0.66 | CFTR (0.77) | CFTRBAZ2BMAPTHDAC1HDAC6 | |
| SCHEMBL1658785 | 0.64 | MAPKAPK2 (1.00) | SIRT1MAPKAPK2MAPKAPK5BAZ2BMAPKAPK3 | |
| SCHEMBL29171356 | 0.63 | BAZ2B (0.82) | CFTRBAZ2BKDR | |
| SCHEMBL12660570 | 0.63 | MAPKAPK2 (1.00) | SIRT1MAPKAPK2MAPKAPK5MAPT | |
| SCHEMBL6235224 | 0.63 | MAPKAPK2 (1.00) | SIRT1MAPKAPK2MAPKAPK5MAPT | |
| SCHEMBL608164 | 0.63 | MAPKAPK2 (1.00) | SIRT1MAPKAPK2MAPKAPK5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999734-B2 | Compounds and compositions for the treatment of cystic fibrosis | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2024-06-04 | — | — | US | claimed |
| EP-3820867-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2023-09-13 | — | — | EP | claimed |
| US-20210292324-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | ISTITUTO GIANNINA GASLINI (IT) | 2021-09-23 | — | — | US | claimed |
| US-11999734-B2 | Compounds and compositions for the treatment of cystic fibrosis | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2024-06-04 | — | — | US | disclosed |
| EP-3820867-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2023-09-13 | — | — | EP | disclosed |
| US-20210292324-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | ISTITUTO GIANNINA GASLINI (IT) | 2021-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11999734-B2 | Compounds and compositions for the treatment of cystic fibrosis | CFTR, ABCB11, ABCC5 | CFTR 1/4885SIRT1 3746/4885MAPKAPK2 4200/4885 |
| US-20210292324-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, ABCB11, ABCC5 | CFTR 1/4885SIRT1 3746/4885MAPKAPK2 4200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.