Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1328891 | 0.85 | FDPS (0.43) | FDPSLMNATSHRFFAR4FFAR1 | |
| SCHEMBL15855762 | 0.85 | FDPS (0.43) | FDPSLMNATSHRFFAR4FFAR1 | |
| SCHEMBL30575792 | 0.85 | FDPS (0.43) | FDPSLMNATSHRFFAR4FFAR1 | |
| SCHEMBL29232764 | 0.85 | FDPS (0.43) | FDPSLMNATSHRFFAR4FFAR1 | |
| SCHEMBL28568549 | 0.85 | FDPS (0.43) | FDPSLMNATSHRFFAR4FFAR1 | |
| SCHEMBL5370957 | 0.82 | — | — | |
| SCHEMBL22249 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL9798772 | 0.78 | FDPS (0.43) | FDPSLMNATSHRFFAR4FFAR1 | |
| Phosphine SCHEMBL27893484 | 0.78 | — | — | |
| SCHEMBL28222123 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086318-A2 | NEUROPROTECTIVE COMPOSITIONS AND METHODS | Burnham Institute for Medical Research (US) | 2009-08-12 | — | — | EP | claimed |
| US-20090042980-A1 | Neuroprotective compositions and methods | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-02-12 | — | — | US | claimed |
| WO-2008108825-A2 | NEUROPROTECTIVE COMPOSITIONS AND METHODS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-09-12 | — | — | WO | claimed |
| US-8466311-B2 | Neuroprotective compositions and methods | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2013-06-18 | — | — | US | disclosed |
| US-20120296112-A1 | Neuroprotective Compositions and Methods | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-11-22 | — | — | US | disclosed |
| US-8022246-B2 | Neuroprotective compositions and methods | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-09-20 | — | — | US | disclosed |
| EP-2086318-A2 | NEUROPROTECTIVE COMPOSITIONS AND METHODS | Burnham Institute for Medical Research (US) | 2009-08-12 | — | — | EP | disclosed |
| US-20090042980-A1 | Neuroprotective compositions and methods | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-02-12 | — | — | US | disclosed |
| WO-2008108825-A2 | NEUROPROTECTIVE COMPOSITIONS AND METHODS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042980-A1 | Neuroprotective compositions and methods | KEAP1, NFE2L2, NQO1 | FDPS 1051/4885LMNA 386/4885TSHR 4756/4885 |
| US-20120296112-A1 | Neuroprotective Compositions and Methods | KEAP1, NFE2L2, NQO1 | FDPS 1051/4885LMNA 386/4885TSHR 4756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.