Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.60 |
| ▸ | HPGD | P15428 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 8/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.60 |
| ▸ | GAA | P10253 | 5/20 | 0.60 |
| ▸ | TP53 | P04637 | 5/20 | 0.60 |
| ▸ | GLA | P06280 | 4/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 9/20 | 0.55 |
| ▸ | NPC1 | O15118 | 8/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL381288 | 0.80 | KDM4E (0.67) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL7898144 | 0.79 | KDM4E (0.62) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL5533172 | 0.79 | KDM4E (0.58) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL11054587 | 0.79 | KDM4E (0.76) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL9149718 | 0.76 | KDM4E (0.63) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL26050351 | 0.76 | KDM4E (0.74) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL10532629 | 0.76 | KDM4E (1.00) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL15616846 | 0.76 | ALDH1A1 (0.80) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL16819879 | 0.74 | KDM4E (0.70) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL2490607 | 0.74 | KDM4E (0.74) | KDM4EALDH1A1HPGDMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220062242-A1 | Methods and compositions for inhibiting mutant EGFR signaling | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2022-03-03 | — | — | US | disclosed |
| US-11123330-B2 | Methods and compositions for inhibiting mutant EGFR signaling | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2021-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11123330-B2 | Methods and compositions for inhibiting mutant EGFR signaling | EGFR, ERBB2, ERBB4 | KDM4E 2737/4885ALDH1A1 4376/4885HPGD 4021/4885 |
| US-20220062242-A1 | Methods and compositions for inhibiting mutant EGFR signaling | EGFR, ERBB2, ERBB4 | KDM4E 2737/4885ALDH1A1 4376/4885HPGD 4021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.