Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CPT1A | P50416 | 1/20 | 0.40 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25482879 | 0.84 | NPC1 (0.52) | EGFRFGFR1KDRMAPTMEN1 | |
| SCHEMBL23833491 | 0.81 | EGFR (0.51) | EGFRFGFR1KDRMAPTMEN1 | |
| SCHEMBL30151007 | 0.81 | EGFR (0.51) | EGFRFGFR1KDRMAPTMEN1 | |
| SCHEMBL23833425 | 0.80 | MEN1 (0.41) | EGFRFGFR1KDRAPOBEC3GMAPT | |
| SCHEMBL23840607 | 0.76 | NPC1 (0.44) | MEN1KMT2AHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL23833405 | 0.76 | MAPT (0.53) | APOBEC3GMAPTMEN1KMT2AHTT | |
| SCHEMBL23833480 | 0.75 | GPR27 (0.48) | MAPTMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL30151063 | 0.75 | GPR27 (0.48) | MAPTMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL23833438 | 0.75 | DRD2 (0.47) | EGFRFGFR1KDRAPOBEC3GMAPT | |
| SCHEMBL30151019 | 0.75 | DRD2 (0.47) | EGFRFGFR1KDRAPOBEC3GMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188907-A1 | PYRIDINESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |