Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.51 |
| ▸ | KDR | P35968 | 9/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23833491 | 1.00 | EGFR (0.51) | EGFRFGFR1KDRMAPK10MAPT | |
| SCHEMBL23846394 | 0.84 | RAB9A (0.48) | EGFRFGFR1KDRMAPK10MAPT | |
| SCHEMBL25482879 | 0.81 | NPC1 (0.52) | EGFRFGFR1KDRMAPTMEN1 | |
| SCHEMBL23840307 | 0.81 | EGFR (0.44) | EGFRFGFR1KDRMAPK10MAPT | |
| SCHEMBL23833405 | 0.77 | MAPT (0.53) | MAPTMEN1HTTKMT2ALMNA | |
| SCHEMBL25754554 | 0.77 | MAPT (0.46) | EGFRFGFR1KDRMAPK10MAPT | |
| SCHEMBL30151063 | 0.76 | GPR27 (0.48) | MAPTMEN1HTTKMT2ALMNA | |
| SCHEMBL23833480 | 0.76 | GPR27 (0.48) | MAPTMEN1HTTKMT2ALMNA | |
| SCHEMBL23833409 | 0.76 | SMN1; SMN2 (0.53) | EGFRFGFR1KDRMAPTMEN1 | |
| SCHEMBL30151054 | 0.76 | SMN1; SMN2 (0.53) | EGFRFGFR1KDRMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4121030-A1 | PYRIDINESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | Amathus Therapeutics, Inc. (US) | 2023-01-25 | — | — | EP | disclosed |