Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 5/20 | 0.64 |
| ▸ | FES | P07332 | 3/20 | 0.60 |
| ▸ | FLT3 | P36888 | 3/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 14/20 | 0.51 |
| ▸ | INSR | P06213 | 4/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.49 |
| ▸ | GAK | O14976 | 3/20 | 0.49 |
| ▸ | IGF1R | P08069 | 3/20 | 0.49 |
| ▸ | LTK | P29376 | 3/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.49 |
| ▸ | TNK1 | Q13470 | 3/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.49 |
| ▸ | INSRR | P14616 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | CLK1 | P49759 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18018796 | 0.89 | TTK (0.80) | TTKFESFLT3ALKINSR | |
| SCHEMBL18018799 | 0.87 | TTK (0.70) | TTKFESFLT3ALKINSR | |
| SCHEMBL18018886 | 0.84 | TTK (0.63) | TTKFESFLT3ALKINSR | |
| SCHEMBL18018865 | 0.81 | TTK (0.68) | TTKFESFLT3ALKINSR | |
| SCHEMBL30381944 | 0.78 | TTK (1.00) | TTKFESFLT3ALKINSR | |
| SCHEMBL17731666 | 0.76 | TTK (1.00) | TTKFESFLT3ALKINSR | |
| SCHEMBL22985902 | 0.76 | TTK (0.54) | TTKFESFLT3ALKINSR | |
| SCHEMBL1545735 | 0.75 | ALK (0.61) | TTKALKINSRFGFR1FGFR2 | |
| SCHEMBL3954048 | 0.75 | FES (1.00) | TTKFESFLT3ALKINSR | |
| SCHEMBL17731758 | 0.74 | TTK (0.75) | TTKFESFLT3ALKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210290624-A1 | METHODS OF TREATING CANCERS CHARACTERIZED BY A HIGH EXPRESSION LEVEL OF SPINDLE AND KINETOCHORE ASSOCIATED COMPLEX SUBUNIT 3 (SKA3) GENE | UNIVERSITY HEALTH NETWORK (CA) | 2021-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210290624-A1 | METHODS OF TREATING CANCERS CHARACTERIZED BY A HIGH EXPRESSION LEVEL OF SPINDLE AND KINETOCHORE ASSOCIATED COMPLEX SUBUNIT 3 (SKA3) GENE | TTBK1, TSSK1B, BRCA1 | TTK 25/4885FES 311/4885FLT3 3263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.