Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 11/20 | 0.47 |
| ▸ | HTR2C | P28335 | 4/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2385456 | 0.87 | TACR1 (0.53) | TACR1HTR2CHTR2AHTR2B | |
| SCHEMBL3911430 | 0.85 | RIPK1 (0.47) | TACR1HTR2CALDH1A1HTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL28230853 | 0.81 | MAOB (0.57) | ALDH1A1MAPT | |
| SCHEMBL1693684 | 0.81 | HTR2C (0.42) | TACR1HTR2CHTR2AHTR2B | |
| SCHEMBL16644630 | 0.80 | SLC6A9 (0.64) | — | |
| SCHEMBL2386164 | 0.80 | DPP4 (0.47) | HTR2CSIGMAR1HTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL28773228 | 0.79 | DPP4 (0.46) | HTR2CHTR2AHTR2B | |
| SCHEMBL11464906 | 0.76 | HTR1A (0.47) | HTR1AHTR2CHTR3EHTR3BALDH1A1 | |
| SCHEMBL11376776 | 0.76 | HTR1A (0.47) | HTR1ATACR1HTR2CHTR3EHTR3B | |
| SCHEMBL20556025 | 0.75 | DPP4 (0.41) | TACR1HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013156-B2 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | disclosed |
| US-20070275952-A1 | Tie-2 Modulators and Methods of Use | EXELIXIS, INC. (US) | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275952-A1 | Tie-2 Modulators and Methods of Use | TIE1, TEK, KDR | HTR1A 3231/4885TACR1 2218/4885HTR2C 2851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.