Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 9/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL513941 | 0.81 | GAA (0.52) | GRM4HTR2BMTNR1AKCNH2MAP4K4 | |
| SCHEMBL23833610 | 0.81 | GRM4 (0.41) | GRM4HTR2BMTNR1AKCNH2MAP4K4 | |
| SCHEMBL30094480 | 0.81 | GRM4 (0.41) | GRM4HTR2BMTNR1AKCNH2MAP4K4 | |
| SCHEMBL30094669 | 0.80 | GRM4 (0.39) | GRM4HTR2BMTNR1AKCNH2MAP4K4 | |
| SCHEMBL23833577 | 0.80 | GRM4 (0.39) | GRM4HTR2BMTNR1AKCNH2MAP4K4 | |
| SCHEMBL515503 | 0.79 | GAA (0.59) | GRM4HTR2BMTNR1AKCNH2L3MBTL1 | |
| SCHEMBL17736002 | 0.77 | GAA (0.57) | GRM4HTR2BMTNR1AKCNH2MAP4K4 | |
| SCHEMBL23144559 | 0.75 | MAOA (0.55) | MAP4K4MELKMAPKAPK2 | |
| SCHEMBL1129152 | 0.75 | ALDH1A1 (0.48) | GRM4HTR2BMTNR1AKCNH2MAP4K4 | |
| SCHEMBL18999306 | 0.72 | GRM4 (0.50) | GRM4HTR2BMTNR1AKCNH2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188938-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE | AKEBIA THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |