Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.40 |
| ▸ | MMP9 | P14780 | 3/20 | 0.40 |
| ▸ | MMP8 | P22894 | 3/20 | 0.40 |
| ▸ | MMP13 | P45452 | 3/20 | 0.40 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25757044 | 0.78 | MEN1 (0.53) | KMT2AMEN1TP53ALDH1A1RAB9A | |
| SCHEMBL3065306 | 0.74 | NR1H4 (0.56) | KMT2APIN1MMP2MMP9MMP8 | |
| SCHEMBL23833381 | 0.74 | PIN1 (0.52) | KMT2AMEN1TP53PIN1MMP2 | |
| SCHEMBL23840648 | 0.74 | PIN1 (0.47) | TP53PIN1MMP2MMP9MMP8 | |
| SCHEMBL25755108 | 0.73 | RXFP1 (0.40) | KMT2AMEN1RAB9ANPC1MAPK1 | |
| SCHEMBL23846523 | 0.73 | RAB9A (0.41) | KMT2AMEN1TP53ALDH1A1HPGD | |
| SCHEMBL23846406 | 0.72 | LMNA (0.47) | KMT2AMEN1TP53PIN1ALDH1A1 | |
| SCHEMBL23846432 | 0.71 | MAPT (0.45) | KMT2AMEN1TP53PIN1ALDH1A1 | |
| SCHEMBL20841762 | 0.70 | MAPT (0.60) | KMT2AMEN1ALDH1A1HPGDNPC1 | |
| SCHEMBL4894537 | 0.70 | MEN1 (0.49) | KMT2AMEN1TP53PIN1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021188880-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |