Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | GRM8 | O00222 | 1/20 | 0.32 |
| ▸ | GRM6 | O15303 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7530109 | 0.82 | GSR (0.54) | GSRBLMCYP1A2THRBNOS1 | |
| Lysine SCHEMBL8199478 | 0.80 | GSR (0.65) | GSRBLMCYP1A2GRM8GRM6 | |
| Alanine SCHEMBL4961214 | 0.80 | GSR (0.59) | GSRBLMCYP1A2THRBNOS1 | |
| Leucine SCHEMBL19692958 | 0.80 | GSR (0.44) | GSRGRIK1SLC1A3SLC1A2SLC1A1 | |
| Lysine SCHEMBL8885814 | 0.80 | GSR (0.48) | GSRBLMCYP1A2SLC1A3SLC1A2 | |
| SCHEMBL3650385 | 0.80 | GSR (0.46) | GSRBLMALOX15PMP22KMT2A | |
| SCHEMBL233577 | 0.80 | ALOX15 (0.44) | GSRBLMALOX15PMP22KMT2A | |
| Glutamine SCHEMBL8045598 | 0.79 | GSR (0.67) | GSRBLMALOX15PMP22KMT2A | |
| Glutamine SCHEMBL19691979 | 0.79 | GSR (0.67) | GSRBLMALOX15PMP22KMT2A | |
| Glutamine SCHEMBL2385066 | 0.78 | GSR (0.54) | GSRBLMALOX15PMP22KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8021646-B2 | Compositions and methods for magnetic resonance imaging contrast agents | NORTHWESTERN UNIVERSITY (US) | 2011-09-20 | — | — | US | disclosed |
| US-20090053141-A1 | COMPOSITIONS AND METHODS FOR MAGNETIC RESONANCE IMAGING CONTRAST AGENTS | NORTHWESTERN UNIVERSITY (US) | 2009-02-26 | — | — | US | disclosed |
| WO-2008073828-A2 | COMPOSITIONS AND METHODS FOR MAGNETIC RESONANCE IMAGING CONTRAST AGENTS | NORTHWESTERN UNIVERSITY (US) | 2008-06-19 | — | — | WO | disclosed |