Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 6/20 | 0.31 |
| ▸ | NOS1 | P29475 | 5/20 | 0.31 |
| ▸ | NOS3 | P29474 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ARG2 | P78540 | 4/20 | 0.31 |
| ▸ | ARG1 | P05089 | 3/20 | 0.31 |
| ▸ | BLM | P54132 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8885814 | 0.85 | GSR (0.48) | GSRRNPEPNOS2NOS1NOS3 | |
| SCHEMBL9780155 | 0.82 | GSR (0.68) | GSRCPB2RNPEPNOS2NOS1 | |
| SCHEMBL2821897 | 0.82 | GSR (0.68) | GSRCPB2RNPEPNOS2NOS1 | |
| Lysine SCHEMBL5410772 | 0.82 | GSR (0.53) | GSRCPB2NOS2NOS1NOS3 | |
| SCHEMBL1389422 | 0.81 | GSR (0.50) | GSRCPB2RNPEPDPP8DPP9 | |
| Lysine SCHEMBL15283763 | 0.81 | GSR (0.71) | GSRCPB2RNPEPNOS2NOS1 | |
| SCHEMBL21988570 | 0.81 | GSR (0.53) | GSRCPB2RNPEPCYP1A2DPP8 | |
| SCHEMBL845919 | 0.81 | GSR (0.53) | GSRCPB2RNPEPCYP1A2DPP8 | |
| Lysine SCHEMBL2385063 | 0.80 | GSR (0.42) | GSRNOS2NOS1NOS3CYP1A2 | |
| Lysine SCHEMBL8199478 | 0.80 | GSR (0.65) | GSRCPB2RNPEPNOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183598-A1 | COMPOSITIONS AND METHODS FOR IDENTIFYING SUBSTRATE SPECIFICITY OF INHIBITORS OF GAMMA SECRETASE | Elan Pharmaceuticals Inc. (US) | 2010-05-12 | — | — | EP | disclosed |
| US-20090163594-A1 | Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors | ELAN PHARMACEUTICALS, INC. (US) | 2009-06-25 | — | — | US | disclosed |
| US-20090023158-A1 | Compositions and Methods for Identifying Substrate Specificity of Inhibitors of Gamma Secretase | ELAN PHARMACEUTICALS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
| WO-2009012237-A1 | COMPOSITIONS AND METHODS FOR IDENTIFYING SUBSTRATE SPECIFICITY OF INHIBITORS OF GAMMA SECRETASE | ELAN PHARMACEUTICALS, INC. (US) | 2009-01-22 | — | — | WO | disclosed |