Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 5/20 | 0.36 |
| ▸ | CNR2 | P34972 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2382190 | 0.83 | F2RL3 (0.46) | F2RL3CNR1CNR2KDM4EMAPK1 | |
| SCHEMBL4577625 | 0.81 | PTGDR2 (0.47) | PTGDR2F2RL3KDM4ECXCR3SMN1; SMN2 | |
| SCHEMBL4771698 | 0.79 | F2RL3 (0.40) | F2RL3CNR1CNR2KDM4EMAPK1 | |
| SCHEMBL2385830 | 0.78 | F2RL3 (0.41) | PTGDR2F2RL3CNR1CNR2KDM4E | |
| SCHEMBL1337093 | 0.77 | GABRA1 (0.39) | F2RL3CNR1CNR2GABRA1GABRG2 | |
| SCHEMBL2384363 | 0.77 | CXCR3 (0.39) | PTGDR2F2RL3MAPTCXCR3SMN1; SMN2 | |
| SCHEMBL2383728 | 0.75 | F2RL3 (0.40) | PTGDR2F2RL3CNR1CNR2KDM4E | |
| SCHEMBL1339573 | 0.75 | KDM4E (0.46) | CNR1CNR2KDM4EGABRA1GABRG2 | |
| SCHEMBL1336873 | 0.72 | GABRA1 (0.42) | F2RL3CNR1CNR2KDM4EGABRA1 | |
| SCHEMBL3572533 | 0.72 | GABRA1 (0.38) | F2RL3CNR1CNR2KDM4EGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012991-B2 | 3-(2,4-dimethoxyphenyl)-1,9-dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]indole-6-carboxylic acid; gamma-aminobutyric acid modulator; anticarcinogenic, antitumor, antiproliferative agent; amidating a 2-aminoindole with an alpha-substituted-beta-hydroxy-alkyl acrylate | SANOFI-AVENTIS (FR) | 2011-09-06 | — | — | US | disclosed |