Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 18/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31694567 | 0.85 | USP30 (0.44) | MEN1KMT2A | |
| SCHEMBL28587989 | 0.85 | KMT2A (0.38) | MEN1KMT2A | |
| SCHEMBL23852703 | 0.74 | ADORA2A (0.47) | P2RY12 | |
| SCHEMBL31629147 | 0.72 | GAA (0.52) | MEN1KMT2A | |
| SCHEMBL21996301 | 0.71 | LMNA (0.45) | — | |
| SCHEMBL30990001 | 0.71 | LMNA (0.45) | — | |
| SCHEMBL14744135 | 0.71 | LMNA (0.45) | — | |
| SCHEMBL5495665 | 0.68 | SMN1; SMN2 (0.49) | MEN1KMT2A | |
| SCHEMBL2357857 | 0.68 | SMN1; SMN2 (0.49) | MEN1KMT2A | |
| SCHEMBL8303596 | 0.68 | SMN1; SMN2 (0.49) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883575-A1 | SUBSTITUTED AMINO TRIAZOLOPYRIMIDINE AND AMINO TRIAZOLOPYRAZINE ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE | Merck Sharp & Dohme Corp. (US) | 2021-09-29 | — | — | EP | disclosed |