Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 18/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23853840 | 0.86 | P2RY12 (0.35) | ADORA2AP2RY12 | |
| SCHEMBL23854039 | 0.85 | ADORA2A (0.50) | ADORA2A | |
| SCHEMBL23854088 | 0.83 | P2RY12 (0.43) | ADORA2AP2RY12 | |
| SCHEMBL23852062 | 0.77 | P2RY12 (0.35) | ADORA2AP2RY12 | |
| SCHEMBL23852060 | 0.77 | P2RY12 (0.35) | ADORA2AP2RY12 | |
| SCHEMBL23851820 | 0.77 | P2RY12 (0.35) | ADORA2AP2RY12 | |
| SCHEMBL23852704 | 0.74 | P2RY12 (0.39) | P2RY12 | |
| SCHEMBL6167984 | 0.70 | P2RY12 (0.44) | P2RY12 | |
| SCHEMBL23040449 | 0.69 | LMNA (0.49) | — | |
| SCHEMBL4709679 | 0.68 | PRMT5 (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883575-A1 | SUBSTITUTED AMINO TRIAZOLOPYRIMIDINE AND AMINO TRIAZOLOPYRAZINE ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE | Merck Sharp & Dohme Corp. (US) | 2021-09-29 | — | — | EP | disclosed |