Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.78 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.78 |
| ▸ | GRK6 | P43250 | 1/20 | 0.76 |
| ▸ | P4HB | P07237 | 5/20 | 0.70 |
| ▸ | RCE1 | Q9Y256 | 2/20 | 0.70 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5090192 | 0.88 | TP53 (1.00) | TP53CYP2C9CYP2C19HIF1AJMJD7 | |
| SCHEMBL14907817 | 0.86 | GRK6 (1.00) | TP53CYP2C9CYP2C19HIF1AJMJD7 | |
| SCHEMBL23854793 | 0.85 | TP53 (0.70) | TP53CYP2C9CYP2C19HIF1AJMJD7 | |
| SCHEMBL21842473 | 0.83 | P4HB (0.81) | TP53CYP2C9CYP2C19HIF1AJMJD7 | |
| SCHEMBL11955293 | 0.83 | P4HB (1.00) | TP53CYP2C9CYP2C19HIF1AJMJD7 | |
| SCHEMBL21842418 | 0.82 | TEAD4 (0.55) | TP53CYP2C9CYP2C19HIF1AJMJD7 | |
| SCHEMBL21842213 | 0.82 | TP53 (0.75) | TP53CYP2C9CYP2C19HIF1AJMJD7 | |
| SCHEMBL9962877 | 0.81 | P4HB (0.77) | TP53CYP2C9CYP2C19HIF1AJMJD7 | |
| SCHEMBL21842411 | 0.81 | TP53 (0.73) | TP53CYP2C9CYP2C19HIF1AJMJD7 | |
| SCHEMBL18197735 | 0.81 | TP53 (0.79) | TP53CYP2C9CYP2C19HIF1AJMJD7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210299070-A1 | METHODS OF TREATING CREATINE TRANSPORTER DEFICIENCY | JNANA THERAPEUTICS INC. | 2021-09-30 | — | — | US | disclosed |
| US-20210300898-A1 | SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS | JNANA THERAPEUTICS INC. | 2021-09-30 | — | — | US | disclosed |
| US-20210299070-A1 | METHODS OF TREATING CREATINE TRANSPORTER DEFICIENCY | JNANA THERAPEUTICS INC. | 2021-09-30 | — | — | US | disclosed |
| US-20210300898-A1 | SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS | JNANA THERAPEUTICS INC. | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300898-A1 | SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS | SNRPE, G3BP1, G3BP2 | TP53 6/4885CYP2C9 4883/4885CYP2C19 4884/4885 |
| US-20210299070-A1 | METHODS OF TREATING CREATINE TRANSPORTER DEFICIENCY | SLC19A1, SLC1A5, SLC1A2 | TP53 4180/4885CYP2C9 3278/4885CYP2C19 3294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.