Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23440876 | 0.88 | PTGDR2 (0.40) | PTGDR2KMT2ALMNAGAAALDH1A1 | |
| SCHEMBL1944113 | 0.81 | CHRM3 (0.43) | KMT2ALMNAGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL4579643 | 0.78 | KDM4E (0.57) | KMT2ALMNAALDH1A1HPGDHTT | |
| SCHEMBL1199476 | 0.77 | ELANE (0.61) | PTGDR2KMT2ALMNAGAAALDH1A1 | |
| SCHEMBL6238224 | 0.76 | PTGDR2 (0.61) | PTGDR2KMT2ALMNAGAAALDH1A1 | |
| SCHEMBL29445574 | 0.76 | PTGDR2 (0.61) | PTGDR2KMT2ALMNAGAAALDH1A1 | |
| SCHEMBL23440887 | 0.76 | HTT (0.43) | LMNAGAAHTTSMN1; SMN2 | |
| SCHEMBL9664970 | 0.75 | KMT2A (0.54) | KMT2AALDH1A1CHRM3MEN1POLB | |
| SCHEMBL9250738 | 0.74 | ELANE (0.49) | KMT2AALDH1A1CHRM3MEN1POLB | |
| SCHEMBL6599026 | 0.74 | CHRM3 (0.45) | KMT2AALDH1A1CHRM3MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126225-A1 | SMALL MOLECULES INDUCING THE DEGRADATION OF THE CELLULAR PRION PROTEIN | Istituto Nazionale di Fisica Nucleare (IT) | 2023-02-08 | — | — | EP | disclosed |
| WO-2021191883-A1 | SMALL MOLECULES INDUCING THE DEGRADATION OF THE CELLULAR PRION PROTEIN | ISTITUTO NAZIONALE DI FISICA NUCLEARE (IT) | 2021-09-30 | — | — | WO | disclosed |