SCHEMBL23856748

SCHEMBL23856748

N#Cc1cccc2c1CC(=O)C2

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.48
TRPA1 O75762 2/20 0.42
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
NOTUM Q6P988 2/20 0.39
MCL1 Q07820 1/20 0.38
CYP2A6 P11509 1/20 0.38
HTR2A P28223 1/20 0.36
HTR2C P28335 1/20 0.36
HTR2B P41595 1/20 0.36
KCNH2 Q12809 1/20 0.36
TYR P14679 1/20 0.35
TSHR P16473 1/20 0.34
PNMT P11086 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
USP8 P40818 1/20 0.32
USP7 Q93009 1/20 0.32
LAP3 P28838 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30253482 1.00 CYP1A2 (0.48) CYP1A2TRPA1CA1CA2NOTUM
SCHEMBL4923692 0.85 TRPA1 (0.53) TRPA1CA1CA2NOTUMMCL1
SCHEMBL21480514 0.85 CYP2A6 (0.48) CYP1A2TRPA1CA1CA2NOTUM
SCHEMBL9190699 0.85 CYP2A6 (0.48) CYP1A2TRPA1CA1CA2NOTUM
Ammonia Solution, Strong SCHEMBL28771343 0.83 TRPA1 (0.51) TRPA1CA1CA2NOTUMMCL1
Hydrochloric Acid SCHEMBL3574165 0.81 TRPA1 (0.53) TRPA1CA1CA2NOTUMMCL1
SCHEMBL28730767 0.72 TRPA1 (0.40) TRPA1CA1CA2NOTUMTYR
SCHEMBL9523617 0.71 CYP1A2 (0.52) CYP1A2CYP2A6TYRTSHRKDM4E
SCHEMBL7008462 0.71 CYP1A2 (0.52) CYP1A2NOTUMCYP2A6TSHRALDH1A1
SCHEMBL9672282 0.71 CYP1A2 (0.52) CYP1A2NOTUMCYP2A6PNMTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4126855-B1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS HOFFMANN LA ROCHE (CH) 2024-04-24 EP disclosed
US-20230242511-A1 FUSED PYRAZOLE AND IMIDAZOLE BASED COMPOUNDS AND USE THEREOF AS GLI1 INHIBITORS GLIXOGEN THERAPEUTICS LTD. (IL) 2023-08-03 US disclosed
US-20230167127-A1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION HOFFMANN-LA ROCHE INC. (US) 2023-06-01 US disclosed
US-20230167127-A1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION HOFFMANN-LA ROCHE INC. (US) 2023-06-01 US disclosed
US-20230167127-A1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION HOFFMANN-LA ROCHE INC. (US) 2023-06-01 US disclosed
EP-4126855-A1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION F. Hoffmann-La Roche AG (CH) 2023-02-08 EP disclosed
WO-2021229583-A1 FUSED PYRAZOLE AND IMIDAZOLE BASED COMPOUNDS AND USE THEREOF AS GLI1 INHIBITORS GLIXOGEN THERAPEUTICS LTD. (IL) 2021-11-18 WO disclosed
WO-2021190727-A1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION F. HOFFMANN-LA ROCHE AG (CH) 2021-09-30 WO disclosed
WO-2021190727-A1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION F. HOFFMANN-LA ROCHE AG (CH) 2021-09-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230167127-A1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION LTB4R, C5, C3AR1 CYP1A2 408/4885TRPA1 708/4885CA1 4207/4885
US-20230242511-A1 FUSED PYRAZOLE AND IMIDAZOLE BASED COMPOUNDS AND USE THEREOF AS GLI1 INHIBITORS GLI1, SHH, GLI2 CYP1A2 3325/4885TRPA1 1450/4885CA1 1179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.