Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 3/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2385757 | 1.00 | LTA4H (0.48) | LTA4HHTR1ATRPV1CYP1A2CYP2E1 | |
| SCHEMBL2383975 | 1.00 | LTA4H (0.48) | LTA4HHTR1ATRPV1CYP1A2CYP2E1 | |
| SCHEMBL2383978 | 1.00 | LTA4H (0.48) | LTA4HHTR1ATRPV1CYP1A2CYP2E1 | |
| (2E)-Hexenoic Acid SCHEMBL2385760 | 0.93 | LTA4H (0.46) | LTA4HHTR1ATRPV1CYP1A2CYP2E1 | |
| SCHEMBL2386952 | 0.87 | THRB (0.48) | HTR1AMET | |
| SCHEMBL2384901 | 0.87 | THRB (0.48) | HTR1AMET | |
| SCHEMBL2384898 | 0.87 | THRB (0.48) | HTR1AMET | |
| SCHEMBL2386951 | 0.87 | THRB (0.48) | HTR1AMET | |
| SCHEMBL2384841 | 0.85 | APP (0.54) | LTA4HHTR1ATRPV1CYP1A2CYP2E1 | |
| SCHEMBL2385829 | 0.85 | APP (0.54) | LTA4HHTR1ATRPV1CYP1A2CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8465939-B2 | Aging-related circulating particle-associated lipoprotein B oxidase (apoBNOX) and inhibitors thereof | NOX TECHNOLOGIES, INC. (US) | 2013-06-18 | — | — | US | disclosed |
| US-20110217401-A1 | Aging-Related Circulating Particle-Associated Lipoprotein B Oxidase (apoBNOX) and Inhibitors Thereof | NOX TECHNOLOGIES, INC. | 2011-09-08 | — | — | US | disclosed |