Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.43 |
| ▸ | RARB | P10826 | 4/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23864630 | 0.81 | RARB (0.42) | PLK1RARBPLK3RARARARG | |
| SCHEMBL9493595 | 0.79 | HDAC3 (0.52) | RARBRARARARGHDAC3HDAC1 | |
| SCHEMBL27999446 | 0.79 | GRIA4 (0.51) | RARBRARARARGALDH1A1MEN1 | |
| SCHEMBL9492798 | 0.78 | HDAC3 (0.51) | RARBRARARARGHDAC3HDAC1 | |
| SCHEMBL28400028 | 0.77 | ALDH1A1 (0.49) | RARBRARARARGALDH1A1MEN1 | |
| SCHEMBL29287569 | 0.76 | CA1 (0.49) | PLK1RARBRARARARGHDAC3 | |
| SCHEMBL23864237 | 0.76 | POLB (0.45) | PLK1PLK3PCSK9ALDH1A1THRA | |
| SCHEMBL20343303 | 0.75 | HDAC3 (0.49) | RARBRARARARGHDAC3HDAC1 | |
| SCHEMBL23864288 | 0.75 | PLK1 (0.49) | PLK1RARBRARAALDH1A1MEN1 | |
| SCHEMBL7786808 | 0.75 | HDAC3 (0.51) | PLK1RARBRARARARGHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968330-B1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | SCRIPPS RESEARCH INST (US) | 2021-09-29 | — | — | EP | disclosed |