Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 2/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23864237 | 0.81 | POLB (0.45) | SMN1; SMN2KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL23864228 | 0.78 | ALDH1A1 (0.40) | SMN1; SMN2KMT2AMAPTALDH1A1POLB | |
| SCHEMBL16127942 | 0.77 | MEN1 (0.49) | SMN1; SMN2KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL16127937 | 0.77 | PLK1 (0.46) | SMN1; SMN2KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL23864298 | 0.72 | ALDH1A1 (0.38) | SMN1; SMN2KMT2AMAPTALDH1A1POLB | |
| SCHEMBL23864567 | 0.71 | POLB (0.50) | SMN1; SMN2KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL14645643 | 0.70 | CYP4A11 (0.54) | SMN1; SMN2KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL16088641 | 0.69 | PLK1 (0.56) | SMN1; SMN2ALDH1A1PLK1PLK3POLB | |
| SCHEMBL16088692 | 0.69 | PLK1 (0.58) | SMN1; SMN2KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL16127933 | 0.68 | ITGB1 (0.52) | CYP3A4PLK1ALOX15ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968330-B1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | SCRIPPS RESEARCH INST (US) | 2021-09-29 | — | — | EP | disclosed |