Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | F13A1 | P00488 | 2/20 | 0.37 |
| ▸ | TGM1 | P22735 | 2/20 | 0.37 |
| ▸ | CCR5 | P51681 | 3/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2386526 | 1.00 | TDP1 (0.42) | TDP1EPHX1ATMTGM2ALDH1A1 | |
| SCHEMBL2386536 | 1.00 | TDP1 (0.42) | TDP1EPHX1ATMTGM2ALDH1A1 | |
| SCHEMBL2384784 | 0.85 | TDP1 (0.46) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL2384773 | 0.85 | TDP1 (0.46) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL2384780 | 0.85 | TDP1 (0.46) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL2384416 | 0.83 | MMP2 (0.48) | TDP1ATMALDH1A1MAPTMMP2 | |
| SCHEMBL2384406 | 0.83 | MMP2 (0.48) | TDP1ATMALDH1A1MAPTMMP2 | |
| SCHEMBL2384410 | 0.83 | MMP2 (0.48) | TDP1ATMALDH1A1MAPTMMP2 | |
| SCHEMBL2065139 | 0.79 | TDP1 (0.50) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL2065141 | 0.79 | TDP1 (0.50) | TDP1ATMALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178554-B2 | Heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents | ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED (IE) | 2012-05-15 | — | — | US | disclosed |
| US-20110213147-A1 | New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents | AVENTIS PHARMA S.A. | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110213147-A1 | New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents | NISCH, DDC, SDHA | TDP1 2979/4885EPHX1 2776/4885ATM 4478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.