Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 7/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 5/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867478 | 0.90 | SRC (0.53) | HRH3HTR2CSRC | |
| SCHEMBL23867510 | 0.82 | HRH3 (0.52) | HRH3HTR2CPTPN11MAPT | |
| SCHEMBL23867482 | 0.81 | HRH3 (0.52) | HRH3HTR2CADORA3CFTRMAPT | |
| SCHEMBL23867476 | 0.81 | HRH3 (0.55) | HRH3HTR2CPTPN11CFTRGABRA1 | |
| SCHEMBL30165658 | 0.78 | HRH3 (0.53) | HRH3HTR2CCFTRGABRA1GABRB1 | |
| SCHEMBL23859943 | 0.78 | HRH3 (0.53) | HRH3HTR2CCFTRGABRA1GABRB1 | |
| SCHEMBL23867490 | 0.77 | HRH3 (0.42) | HRH3ADORA3SRCMAPT | |
| SCHEMBL23867519 | 0.73 | HTR2A (0.51) | HRH3HTR2CPTPN11SRC | |
| SCHEMBL23867489 | 0.73 | MGLL (0.44) | ADORA3SRCMAPT | |
| SCHEMBL23867522 | 0.72 | HTR2A (0.53) | HRH3HTR2CSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |