Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.43 |
| ▸ | TCF7L2 | Q9NQB0 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867522 | 0.90 | HTR2A (0.53) | HRH3PTGDR2HTR2CHTR2A | |
| SCHEMBL23867510 | 0.85 | HRH3 (0.52) | HRH3MAPTHTR2CNPC1RAB9A | |
| SCHEMBL23859943 | 0.82 | HRH3 (0.53) | HRH3PTGDR2MAPTHTR2CNPC1 | |
| SCHEMBL30165658 | 0.82 | HRH3 (0.53) | HRH3PTGDR2MAPTHTR2CNPC1 | |
| SCHEMBL23867481 | 0.81 | HRH3 (0.51) | HRH3MAPTHTR2CADORA3CFTR | |
| SCHEMBL23867581 | 0.79 | HTR2A (0.40) | MAPTHTR2CHTR2A | |
| SCHEMBL23867577 | 0.78 | HTR2A (0.51) | HTR2CCTNNB1TCF7L2HTR2A | |
| SCHEMBL23867476 | 0.78 | HRH3 (0.55) | HRH3PTGDR2HTR2CCFTR | |
| SCHEMBL30979647 | 0.76 | HTR2C (0.56) | HRH3PTGDR2MAPTHTR2CNPC1 | |
| SCHEMBL23867507 | 0.76 | HTR2A (0.39) | MAPTHTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |