Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 7/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867482 | 0.90 | HRH3 (0.52) | HTR2AHTR2CHRH3PTGDR2 | |
| SCHEMBL23867577 | 0.88 | HTR2A (0.51) | HTR2AHTR2CSRCDRD3 | |
| SCHEMBL23867519 | 0.86 | HTR2A (0.51) | HTR2AHTR2CSRCDRD3HRH3 | |
| SCHEMBL23867521 | 0.84 | HTR1A (0.50) | HTR2AHTR2CSRCDRD3HRH3 | |
| SCHEMBL23867478 | 0.83 | SRC (0.53) | HTR2AHTR2CSRCDRD3HRH3 | |
| SCHEMBL23867512 | 0.80 | ACHE (0.50) | HTR2AHTR2CSRCDRD3HRH3 | |
| SCHEMBL23867525 | 0.76 | HTR2A (0.49) | HTR2AHTR2CSRCDRD3 | |
| SCHEMBL23867510 | 0.75 | HRH3 (0.52) | HTR2CHRH3 | |
| SCHEMBL23859943 | 0.73 | HRH3 (0.53) | HTR2CHRH3PTGDR2 | |
| SCHEMBL30165658 | 0.73 | HRH3 (0.53) | HTR2CHRH3PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |