Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CHKA | P35790 | 1/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19176320 | 0.87 | NPC1 (0.45) | NPC1RAB9AHPGDTP53ALDH1A1 | |
| SCHEMBL4904859 | 0.82 | ALDH1A1 (0.49) | NPC1RAB9AHPGDALDH1A1KDM4E | |
| SCHEMBL2494508 | 0.81 | TSHR (0.35) | ALDH1A1KDM4ETHRBHRH3LTA4H | |
| SCHEMBL4814954 | 0.81 | KDM4E (0.36) | NPC1RAB9AHPGDTP53ALDH1A1 | |
| SCHEMBL19275284 | 0.81 | ALDH1A1 (0.44) | NPC1RAB9ATP53ALDH1A1KDM4E | |
| SCHEMBL27249931 | 0.80 | ALOX15 (0.39) | NPC1RAB9AHPGDALDH1A1KDM4E | |
| SCHEMBL3314123 | 0.79 | TSHR (0.38) | ALDH1A1THRBHRH3LTA4H | |
| SCHEMBL21477059 | 0.78 | GNAI3 (0.43) | NPC1RAB9AHPGDTP53ALDH1A1 | |
| SCHEMBL5892364 | 0.76 | TSHR (0.42) | NPC1RAB9AHPGDTP53ALDH1A1 | |
| SCHEMBL3304899 | 0.76 | ALDH1A1 (0.43) | ALDH1A1KDM4EUSP2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195599-A1 | MTORC1 MODULATORS AND USES THEREOF | AEOVIAN PHARMACEUTICALS, INC. (US) | 2021-09-30 | — | — | WO | disclosed |