Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.65 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.57 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.54 |
| ▸ | METAP1 | P53582 | 2/20 | 0.53 |
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11770396 | 0.83 | AURKA (0.70) | AURKAHPSEPRMT5METAP1METAP2 | |
| SCHEMBL6265481 | 0.83 | AURKA (0.68) | AURKAHPSEPRMT5METAP1METAP2 | |
| SCHEMBL28693174 | 0.83 | AURKA (0.68) | AURKAHPSEPRMT5METAP1METAP2 | |
| SCHEMBL14090269 | 0.82 | PDE5A (0.57) | AURKAHPSEMETAP1METAP2HDAC6 | |
| Hydrochloric Acid SCHEMBL11772488 | 0.81 | AURKA (0.66) | AURKAHPSEPRMT5METAP1METAP2 | |
| SCHEMBL1284270 | 0.80 | AURKA (0.73) | AURKAHPSEPRMT5METAP1METAP2 | |
| SCHEMBL7434682 | 0.80 | AURKA (0.68) | AURKAHPSEPRMT5METAP1METAP2 | |
| SCHEMBL28223244 | 0.80 | AURKA (0.68) | AURKAHPSEPRMT5METAP1METAP2 | |
| Hydrochloric Acid SCHEMBL11776694 | 0.79 | AURKA (0.71) | AURKAHPSEPRMT5METAP1METAP2 | |
| SCHEMBL11155883 | 0.79 | AURKA (0.67) | AURKAHPSEPRMT5METAP1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300877-A1 | 2-ARYLBENZIMIDAZOLES AS PPARGC1A ACTIVATORS FOR TREATING NEURODEGENERATIVE DISEASES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300877-A1 | 2-ARYLBENZIMIDAZOLES AS PPARGC1A ACTIVATORS FOR TREATING NEURODEGENERATIVE DISEASES | PPARG, PPARA, PPARD | AURKA 4290/4885HPSE 3663/4885PRMT5 3101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.