Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.68 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.61 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.58 |
| ▸ | METAP1 | P53582 | 2/20 | 0.57 |
| ▸ | METAP2 | P50579 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1284270 | 0.84 | AURKA (0.73) | AURKAHPSENPC1RAB9APRMT5 | |
| SCHEMBL7434682 | 0.83 | AURKA (0.68) | AURKAHPSEPRMT5METAP1METAP2 | |
| SCHEMBL28223244 | 0.83 | AURKA (0.68) | AURKAHPSEKDM4ENPC1TP53 | |
| SCHEMBL28693174 | 0.83 | AURKA (0.68) | AURKAHPSETP53POLBSMN1; SMN2 | |
| SCHEMBL11770396 | 0.83 | AURKA (0.70) | AURKAHPSENPC1HPGDRAB9A | |
| Hydrochloric Acid SCHEMBL11776694 | 0.83 | AURKA (0.71) | AURKAHPSENPC1RAB9APRMT5 | |
| SCHEMBL11155883 | 0.83 | AURKA (0.67) | AURKAHPSENUDT1KDM4EALDH1A1 | |
| SCHEMBL23870533 | 0.83 | AURKA (0.65) | AURKAHPSEPRMT5METAP1METAP2 | |
| Hydrochloric Acid SCHEMBL11772488 | 0.82 | AURKA (0.66) | AURKAHPSETP53POLBSMN1; SMN2 | |
| SCHEMBL1170747 | 0.82 | METAP1 (0.72) | AURKAHPSENUDT1PRMT5METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005030206-A1 | ARYL-1,3-AZOLE DERIVATIVES AND METHODS FOR INHIBITING HEPARNASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-04-07 | — | — | WO | disclosed |