SCHEMBL2387307

CCO[C@H](C)COCc1ccc([C@H]2C[C@@H](COS(C)(=O)=O)N(S(=O)(=O)c3ccc(C)cc3)C[C@@H]2OCc2ccc3c(c2)N(CCCOC)CCO3)cc1

nearest known ligand 0.30

Predicted protein targets (top 2)

	gene	UniProt	supporting neighbours	confidence
▸	REN	P00797	1/20	0.30

▸	CYP2C9	P11712	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2387367	0.96	CASP3 (0.30)	—
SCHEMBL2388140	0.94	REN (0.32)	RENCYP2C9
SCHEMBL2393016	0.93	—	—
SCHEMBL2390336	0.93	CYP2C9 (0.32)	RENCYP2C9
SCHEMBL2390330	0.93	CYP2C9 (0.32)	RENCYP2C9
SCHEMBL2388183	0.93	REN (0.31)	RENCYP2C9
SCHEMBL1517865	0.93	CYP2C9 (0.31)	RENCYP2C9
SCHEMBL2389129	0.93	REN (0.31)	REN
SCHEMBL2389125	0.93	RORC (0.32)	RENCYP2C9
SCHEMBL2389128	0.93	REN (0.32)	RENCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-8022069-B2	Substituted piperidines as renin inhibitors	NOVARTIS AG (CH)	2011-09-20	—	—	US	disclosed