Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.30 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12562945 | 0.78 | ADORA2A (0.41) | ADORA2AADORA2BADORA1KDM4EALDH1A1 | |
| SCHEMBL23876557 | 0.75 | PTGER4 (0.35) | KDM4EALDH1A1NOS3NOS1NOS2 | |
| SCHEMBL19366625 | 0.73 | DCTPP1 (0.36) | ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL31210378 | 0.71 | ADORA2A (0.46) | ADORA2AADORA2BADORA1KDM4EALDH1A1 | |
| SCHEMBL23459658 | 0.71 | RPS6KA3 (0.38) | EGFRKDM4EALDH1A1RAB9AGAA | |
| SCHEMBL23876548 | 0.66 | PTGER4 (0.42) | ALDH1A1NOS3NOS1HTTTP53 | |
| SCHEMBL9386422 | 0.64 | USP14 (0.43) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL19939403 | 0.64 | ADORA2A (0.36) | ADORA2AADORA2BADORA1KDM4ESMN1; SMN2 | |
| SCHEMBL23109112 | 0.63 | PTGER4 (0.36) | KDM4EALDH1A1HPGDHTTTSHR | |
| SCHEMBL21621541 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300921-A1 | EP4 INHIBITORS AND SYNTHESIS THEREOF | ASKAT INC. (JP) | 2021-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300921-A1 | EP4 INHIBITORS AND SYNTHESIS THEREOF | PTGER4, EPB41, CDK4 | EGFR 986/4885ADORA2A 3501/4885ADORA2B 2037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.