Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9964996 | 0.77 | ALDH1A1 (0.35) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL15088135 | 0.71 | ALDH1A1 (0.37) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL7521680 | 0.70 | NPC1 (0.44) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL18760647 | 0.70 | PLAU (0.33) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL19275524 | 0.70 | PLAU (0.34) | KDM4EMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL3731779 | 0.69 | NR4A1 (0.50) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL11227025 | 0.69 | NR4A1 (0.50) | NPC1RAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL25375145 | 0.68 | NPC1 (0.45) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL7101276 | 0.67 | CA12 (0.63) | KDM4EMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL16317121 | 0.67 | CA12 (0.63) | KDM4EMAPTNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021194914-A1 | SUBSTITUTED OXOISOINDOLINE COMPOUNDS FOR THE TREATMENT OF CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-09-30 | — | — | WO | disclosed |