SCHEMBL23877468

SCHEMBL23877468

O=C(NC12CC(c3ccccc3)(C1)C2)c1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(-n2cnnn2)cc1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ USP2 O75604 5/20 0.44
▸ USP8 P40818 5/20 0.44
▸ ACLY P53396 4/20 0.44
▸ USP36 Q9P275 1/20 0.44
▸ MEN1 O00255 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ KDM1A O60341 1/20 0.41
▸ MCL1 Q07820 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ GPR27 Q9NS67 2/20 0.39
▸ AVPR2 P30518 1/20 0.39
▸ NSD2 O96028 1/20 0.39
▸ DUSP3 P51452 1/20 0.39
▸ PTPN5 P54829 1/20 0.39
▸ PTPN11 Q06124 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31046840 1.00 USP2 (0.44) USP2USP8ACLYUSP36MEN1
SCHEMBL23877491 0.90 MEN1 (0.45) USP2USP8ACLYUSP36MEN1
SCHEMBL30547568 0.90 MEN1 (0.45) USP2USP8ACLYUSP36MEN1
SCHEMBL23877568 0.85 USP2 (0.47) USP2USP8ACLYUSP36MEN1
SCHEMBL29460194 0.85 USP2 (0.47) USP2USP8ACLYUSP36MEN1
SCHEMBL23877572 0.83 USP2 (0.49) USP2USP8ACLYUSP36MEN1
SCHEMBL23877465 0.82 USP2 (0.47) USP2USP8ACLYUSP36MEN1
SCHEMBL23141388 0.81 USP2 (0.47) USP2USP8ACLYUSP36MEN1
SCHEMBL23877582 0.81 USP2 (0.47) USP2USP8ACLYUSP36MEN1
SCHEMBL31046899 0.81 USP2 (0.47) USP2USP8ACLYUSP36KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2026-04-21 — — US disclosed
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO, INC. 2024-12-12 — — US disclosed
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2024-07-30 — — US disclosed
EP-3796975-B1 SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO INC (US) 2023-08-30 — — EP disclosed
EP-3796975-B1 SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO INC (US) 2023-08-30 — — EP disclosed
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES GILEAD SCIENCES, INC. 2022-02-24 — — US disclosed
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives THE LIVER COMPANY INC. (US) 2021-10-05 — — US disclosed
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives THE LIVER COMPANY INC. (US) 2021-10-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B USP2 3178/4885USP8 3142/4885ACLY 2228/4885
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B USP2 3178/4885USP8 3142/4885ACLY 2228/4885
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives NR3C2, NR5A1, SRD5A2 USP2 3926/4885USP8 3201/4885ACLY 1624/4885
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B USP2 3178/4885USP8 3142/4885ACLY 2228/4885
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B USP2 3178/4885USP8 3142/4885ACLY 2228/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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