SCHEMBL23877484

SCHEMBL23877484

O=C(NC12CC(C(F)(F)F)(C1)C2)c1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ACLY P53396 3/20 0.52
▸ USP2 O75604 5/20 0.52
▸ USP8 P40818 5/20 0.52
▸ KDM1A O60341 2/20 0.51
▸ MEN1 O00255 1/20 0.49
▸ GAA P10253 1/20 0.49
▸ KMT2A Q03164 1/20 0.49
▸ USP36 Q9P275 1/20 0.49
▸ ALDH1A1 P00352 1/20 0.47
▸ LMNA P02545 1/20 0.47
▸ GPR27 Q9NS67 5/20 0.47
▸ AVPR2 P30518 4/20 0.47
▸ CCR1 P32246 1/20 0.46
▸ CCR2 P41597 1/20 0.46
▸ KCNA5 P22460 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30547620 1.00 ACLY (0.52) ACLYUSP2USP8KDM1AMEN1
SCHEMBL23877472 0.91 KDM1A (0.50) ACLYUSP2USP8KDM1AUSP36
SCHEMBL31046884 0.91 KDM1A (0.50) ACLYUSP2USP8KDM1AUSP36
SCHEMBL23879636 0.91 KDM1A (0.50) ACLYUSP2USP8KDM1AMEN1
SCHEMBL23877473 0.90 KDM1A (0.49) ACLYUSP2USP8KDM1AUSP36
SCHEMBL23877599 0.90 KDM1A (0.49) ACLYUSP2USP8KDM1AUSP36
SCHEMBL23877479 0.90 KDM1A (0.49) ACLYUSP2USP8KDM1AUSP36
SCHEMBL23877433 0.90 KDM1A (0.49) ACLYUSP2USP8KDM1AUSP36
SCHEMBL23877474 0.90 KDM1A (0.49) ACLYUSP2USP8KDM1AUSP36
SCHEMBL23141234 0.90 KDM1A (0.47) ACLYUSP2USP8KDM1AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2026-04-21 — — US disclosed
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO, INC. 2024-12-12 — — US disclosed
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives ORSOBIO, INC. (US) 2024-07-30 — — US disclosed
EP-3796975-B1 SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO INC (US) 2023-08-30 — — EP disclosed
EP-3796975-B1 SULFONYLAMINOBENZAMIDE DERIVATIVES ORSOBIO INC (US) 2023-08-30 — — EP disclosed
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES GILEAD SCIENCES, INC. 2022-02-24 — — US disclosed
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives THE LIVER COMPANY INC. (US) 2021-10-05 — — US disclosed
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives THE LIVER COMPANY INC. (US) 2021-10-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220055985-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B ACLY 2228/4885USP2 3178/4885USP8 3142/4885
US-12049439-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B ACLY 2228/4885USP2 3178/4885USP8 3142/4885
US-12606522-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives NR3C2, NR5A1, SRD5A2 ACLY 1624/4885USP2 3926/4885USP8 3201/4885
US-20240409508-A1 SULFINYLAMINOBENZAMIDE AND SULFONYLAMINOBENZAMIDE DERIVATIVES STS, SULT2A1, SCN2B ACLY 2228/4885USP2 3178/4885USP8 3142/4885
US-11136290-B2 Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives STS, SULT2A1, SCN2B ACLY 2228/4885USP2 3178/4885USP8 3142/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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