Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 4/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL722211 | 0.79 | KDM4E (0.38) | KDM4EALDH1A1PDE2ADPP4FAP | |
| SCHEMBL194271 | 0.74 | KDM4E (0.40) | KDM4EALDH1A1PDE2ADPP4FAP | |
| SCHEMBL253085 | 0.71 | CYP27A1 (0.44) | KDM4EALDH1A1HSD11B1DPP4FAP | |
| Ammonia Solution, Strong SCHEMBL5763323 | 0.64 | KDM4E (0.50) | KDM4EALDH1A1HSD11B1ATMGAA | |
| SCHEMBL11790789 | 0.64 | CYP27A1 (0.46) | KDM4EALDH1A1HSD11B1SLC6A2SLC6A4 | |
| SCHEMBL28793486 | 0.63 | KDM4E (0.41) | KDM4EALDH1A1HSD11B1DPP4FAP | |
| SCHEMBL3725189 | 0.62 | IDO1 (0.46) | KDM4EALDH1A1ATMGAANPSR1 | |
| SCHEMBL21523663 | 0.62 | ALDH1A1 (0.66) | KDM4EALDH1A1ATMGAANPSR1 | |
| SCHEMBL3551332 | 0.62 | HSD11B1 (0.64) | KDM4EALDH1A1HSD11B1NPSR1SLC6A2 | |
| SCHEMBL13036871 | 0.60 | KDM4E (0.47) | KDM4EALDH1A1HSD11B1ATMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401276-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS | Eisai R&D Management Co., Ltd. (JP) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010098487-A1 | NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-09-02 | — | — | WO | disclosed |