Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ASAH2 | Q9NR71 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19522459 | 0.84 | HDAC2 (0.40) | HDAC2MEN1KMT2AFAAHMAPK1 | |
| SCHEMBL23879484 | 0.83 | MEN1 (0.40) | MEN1KMT2AFAAHMAPK1ALDH1A1 | |
| SCHEMBL16664145 | 0.83 | MEN1 (0.40) | MEN1KMT2AFAAHMAPK1ALDH1A1 | |
| SCHEMBL22294196 | 0.81 | HDAC2 (0.42) | HDAC2FAAHALDH1A1MAPTASAH2 | |
| SCHEMBL16664143 | 0.80 | MEN1 (0.38) | MEN1KMT2AFAAHMAPK1ALDH1A1 | |
| SCHEMBL12352426 | 0.79 | HDAC2 (0.41) | HDAC2FAAHALDH1A1MAPTASAH2 | |
| SCHEMBL6326746 | 0.74 | HDAC2 (0.57) | HDAC2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL28216590 | 0.74 | ALDH1A1 (0.39) | HDAC2KMT2AALDH1A1MAPTFPR2 | |
| SCHEMBL6326750 | 0.74 | HDAC2 (0.57) | HDAC2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL5692283 | 0.71 | MAPK1 (0.45) | MEN1KMT2AFAAHMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136327-B2 | Macrocycles as factor XIA inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11136327-B2 | Macrocycles as factor XIA inhibitors | TFPI, TFPI2, F11 | HDAC2 649/4885MEN1 376/4885KMT2A 1111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.