Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | ASAH2 | Q9NR71 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16664145 | 1.00 | MEN1 (0.40) | MEN1KMT2AFAAHMAPK1TSHR | |
| SCHEMBL25063463 | 0.85 | TAS1R3 (0.42) | MEN1KMT2AFAAHMAPK1TSHR | |
| SCHEMBL19522400 | 0.83 | TSHR (0.36) | MEN1KMT2AFAAHMAPK1TSHR | |
| SCHEMBL19522458 | 0.83 | TSHR (0.36) | MEN1KMT2AFAAHMAPK1TSHR | |
| SCHEMBL23879485 | 0.83 | HDAC2 (0.43) | MEN1KMT2AFAAHMAPK1TSHR | |
| SCHEMBL10257664 | 0.83 | TSHR (0.36) | MEN1KMT2AFAAHMAPK1TSHR | |
| SCHEMBL19522452 | 0.83 | TSHR (0.36) | MEN1KMT2AFAAHMAPK1TSHR | |
| SCHEMBL22294481 | 0.82 | ALDH1A1 (0.33) | MEN1KMT2ATSHRALDH1A1MAPT | |
| SCHEMBL22294295 | 0.82 | ALDH1A1 (0.33) | MEN1KMT2ATSHRALDH1A1MAPT | |
| SCHEMBL22294369 | 0.82 | ALDH1A1 (0.33) | MEN1KMT2ATSHRALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136327-B2 | Macrocycles as factor XIA inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11136327-B2 | Macrocycles as factor XIA inhibitors | TFPI, TFPI2, F11 | MEN1 376/4885KMT2A 1111/4885FAAH 1891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.