Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL23883176 | 0.85 | CYP1A2 (0.47) | — | |
| SCHEMBL4267103 | 0.79 | CA12 (0.63) | GRM5CA12CA1CA2CA9 | |
| Bromide SCHEMBL23883172 | 0.79 | GRM5 (0.45) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL20364509 | 0.78 | GRM5 (0.51) | GRM5CA12CA1CA2CA9 | |
| Bromide SCHEMBL17048143 | 0.77 | APP (0.50) | GRM5 | |
| SCHEMBL6132140 | 0.77 | GRM5 (0.66) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL30707880 | 0.77 | GRM5 (0.66) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL6784118 | 0.76 | GRM5 (0.49) | GRM5CA12CA1CA2CA9 | |
| Bromide SCHEMBL23883178 | 0.76 | CA12 (0.41) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL30172141 | 0.75 | FFAR1 (0.44) | GRM5CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12616753-B2 | HSP70 inhibitors and methods of using same | THE WISTAR INSTITUTE (US) | 2026-05-05 | — | — | US | disclosed |
| WO-2021202540-A1 | HSP70 INHIBITORS AND METHODS OF USING SAME | THE WISTAR INSTITUTE (US) | 2021-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12616753-B2 | HSP70 inhibitors and methods of using same | HSPB1, HSP90AB1, HSF1 | CHRM2 1590/4885CHRM1 916/4885CHRM3 2277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.