Sugi Predict

Sugi Predict / Compounds / Bromide

Bromide

Bromide

SCHEMBL23883172

Cc1cccc(C#C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c1.[Br-]

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ACHE known ✓ P22303 1/20 0.37
▸ GRM5 P41594 6/20 0.45
▸ FFAR1 O14842 4/20 0.40
▸ FFAR4 Q5NUL3 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ PTGES O14684 1/20 0.36
▸ GABRP O00591 1/20 0.35
▸ GABRD O14764 1/20 0.35
▸ GABRA1 P14867 1/20 0.35
▸ GABRB1 P18505 1/20 0.35
▸ GABRG2 P18507 1/20 0.35
▸ GABRB3 P28472 1/20 0.35
▸ GABRA5 P31644 1/20 0.35
▸ GABRA3 P34903 1/20 0.35
▸ GABRA2 P47869 1/20 0.35
▸ GABRB2 P47870 1/20 0.35
▸ GABRA4 P48169 1/20 0.35
▸ GABRE P78334 1/20 0.35
▸ GABRA6 Q16445 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL17048143 0.81 APP (0.50) GRM5SMN1; SMN2NPSR1
Bromide SCHEMBL23883178 0.79 CA12 (0.41) GRM5CA12CA1CA2CA9
Bromide SCHEMBL23883180 0.79 GRM5 (0.46) GRM5FFAR1PTGESCA12CA1
SCHEMBL28472086 0.79 GRM5 (0.47) GRM5FFAR1FFAR4ACHEPTGES
SCHEMBL4946180 0.77 GRM5 (0.62) GRM5FFAR1FFAR4SMN1; SMN2ACHE
SCHEMBL29288275 0.75 GRM5 (0.47) GRM5FFAR1FFAR4PTGESGABRP
SCHEMBL4562089 0.74 GRM5 (0.69) GRM5FFAR1FFAR4HTTSMN1; SMN2
SCHEMBL30469478 0.74 GRM5 (0.69) GRM5FFAR1FFAR4HTTSMN1; SMN2
SCHEMBL30469481 0.74 GRM5 (0.69) GRM5FFAR1FFAR4HTTSMN1; SMN2
Bromide SCHEMBL23883201 0.74 ASIC3 (0.40) CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12616753-B2 HSP70 inhibitors and methods of using same THE WISTAR INSTITUTE (US) 2026-05-05 — — US disclosed
US-20230158146-A1 HSP70 Inhibitors and Methods of Using Same THE WISTAR INST (US) 2023-05-25 — — US disclosed
WO-2021202540-A1 HSP70 INHIBITORS AND METHODS OF USING SAME THE WISTAR INSTITUTE (US) 2021-10-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230158146-A1 HSP70 Inhibitors and Methods of Using Same HSPA2, HSPBP1, HSP90AB1 ACHE 3194/4885GRM5 4448/4885FFAR1 4591/4885
US-12616753-B2 HSP70 inhibitors and methods of using same HSPB1, HSP90AB1, HSF1 ACHE 3921/4885GRM5 4332/4885FFAR1 3703/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.