Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23884840 | 1.00 | ALDH1A1 (0.37) | ALDH1A1TSHRHCRTR2HCRTR1MEN1 | |
| SCHEMBL25718953 | 0.85 | CYP4F2 (0.47) | ALDH1A1TSHRHCRTR2MEN1KMT2A | |
| SCHEMBL30177262 | 0.85 | CYP4F2 (0.47) | ALDH1A1TSHRHCRTR2MEN1KMT2A | |
| SCHEMBL23884672 | 0.81 | HCRTR2 (0.52) | HCRTR2HCRTR1LMNATP53 | |
| SCHEMBL23884669 | 0.81 | HCRTR2 (0.52) | HCRTR2HCRTR1LMNATP53 | |
| SCHEMBL23884864 | 0.79 | ALDH1A1 (0.47) | ALDH1A1TSHRHCRTR2HCRTR1 | |
| SCHEMBL23884865 | 0.79 | ALDH1A1 (0.47) | ALDH1A1TSHRHCRTR2HCRTR1 | |
| SCHEMBL23884691 | 0.78 | MEN1 (0.39) | ALDH1A1TSHRHCRTR2MEN1KMT2A | |
| SCHEMBL23884663 | 0.77 | THRA (0.40) | THRATHRBPTGER1PTGER4PTGER3 | |
| SCHEMBL23884662 | 0.77 | THRA (0.40) | THRATHRBPTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192611-A1 | MODULATORS OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2023-06-22 | — | — | US | disclosed |
| EP-4126832-A1 | MODULATORS OF HEMOGLOBIN | Global Blood Therapeutics, Inc. (US) | 2023-02-08 | — | — | EP | disclosed |
| WO-2021202284-A1 | MODULATORS OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192611-A1 | MODULATORS OF HEMOGLOBIN | HBG1, HBG2, HBB | ALDH1A1 1650/4885TSHR 2136/4885HCRTR2 4782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.